2-Chloroethyl isocyanate → HCID 90427244、化合物
反応式
[CH3:1][O:2][CH2:3][C@@H:4]([NH2:6])[CH3:5].[Cl:7][CH2:8][CH2:9][N:10]=[C:11]=[O:12]>C1COCC1>[Cl:7][CH2:8][CH2:9][NH:10][C:11]([NH:6][C@@H:4]([CH3:5])[CH2:3][O:2][CH3:1])=[O:12]参加物
4
実験手順
A solution of (S)-1-methoxypropan-2-amine (500 mg, 5.61 mmol) in THF (15 mL) was treated with 2-chloroethylisocyanate (592 mg, 5.61 mmol), stirred at RT overnight, then concentrated to dryness. The residue was treated with toluene and concentrated to dryness (twice) to afford (S)-1-(2-chloroethyl)-3-(1-methoxypropan-2-yl)urea (100% yield assumed) as a white solid which was used without further purification. MS (ESI) m/z: 195.1 (M+H+).
後処理
- concentrationconcentrated to dryness
- additionThe residue was treated with toluene
- concentrationconcentrated to dryness (twice)
出典と根拠
- ORDレコード
- ord-d2ddf7a07f8248d79ec25eea7f74d719
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09133183B2
反応ノート
読み込み中…