Hydrochloric Acid → HCID 178436766、化合物

HRID 2279121ノート

反応式

HRID 2279121 の反応式
C(OC([N:8]1[CH2:13][C:12]([CH3:15])([CH3:14])[N:11]([CH2:16][C:17]2[CH:22]=[C:21]([C:23]3[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=3)[N:20]=[C:19]3[N:30](C4CCCCO4)[N:31]=[C:32]([CH3:33])[C:18]=23)[CH2:10][C:9]1([CH2:41][CH3:42])[CH3:40])=O)(C)(C)C.Cl>C1COCC1>[CH2:41]([C:9]1([CH3:40])[CH2:10][N:11]([CH2:16][C:17]2[CH:22]=[C:21]([C:23]3[CH:24]=[CH:25][C:26]([OH:29])=[CH:27][CH:28]=3)[N:20]=[C:19]3[NH:30][N:31]=[C:32]([CH3:33])[C:18]=23)[C:12]([CH3:15])([CH3:14])[CH2:13][NH:8]1)[CH3:42]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 1366232192-Ethyl-4-[6-(4-hydroxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-ylmethyl]-2,5,5-trimethyl-piperazine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 178436766HCID 178436766、化合物収率 61.8%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
40 °C

実験手順

19 mg of 2-ethyl-4-[6-(4-hydroxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-ylmethyl]-2,5,5-trimethyl-piperazine-1-carboxylic acid tert-butyl ester were dissolved in 0.4 ml of THF and treated with 1.5 ml of hydrochloric acid (4M in dry dioxane). After stirring at rt overnight and at 40° C. for 2 h the volatiles were removed in vacuo. The residue was triturated with dioxane and the resulting solid was isolated by suction. 8 mg (57%) of the title compound were obtained.

後処理

  1. customwere removed in vacuo
  2. customThe residue was triturated with dioxane
  3. customthe resulting solid was isolated by suction

出典と根拠

ORDレコード
ord-8c54dec5c7644dbdb46ba62eb7eb7dea
出典データセット
uspto-grants-2015_09
特許番号
US09133181B2

反応ノート

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