N-bromobutanimide → HCID 178487833、化合物

HRID 2279424ノート

反応式

HRID 2279424 の反応式
[Br:1]N1C(=O)CCC1=O.[CH3:9][O:10][C:11]1[N:12]=[C:13]2[C:18](=[CH:19][CH:20]=1)[N:17]=[CH:16][CH:15]=[C:14]2[OH:21]>C(O)(=O)C>[Br:1][C:15]1[CH:16]=[N:17][C:18]2[C:13]([C:14]=1[OH:21])=[N:12][C:11]([O:10][CH3:9])=[CH:20][CH:19]=2

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 178487891HCID 178487891、化合物

生成物 1

HCID 178487833HCID 178487833、化合物収率 97%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
15 °C

実験手順

N-Bromosuccinimide (263 mg, 1.48 mmol, 1.3 eq) is added at 15° C. to a stirred solution of 6-methoxy-[1,5]naphthyridin-4-ol (200 mg, 1.14 mmol, 1.0 eq) in acetic acid (3 mL). After 30 minutes stirring at 15° C., the reaction mixture is allowed to come at room temperature and the resulting cake is filtered, washed with acetic acid and dried to afford 3-bromo-6-methoxy-[1,5]naphthyridin-4-ol as an off-white solid (280 mg, 97% yield).

後処理

  1. customto come at room temperature
  2. filtrationthe resulting cake is filtered
  3. washwashed with acetic acid
  4. customdried

出典と根拠

ORDレコード
ord-485e4ec02d84414d902e065ee15a946b
出典データセット
uspto-grants-2015_09
特許番号
US09133219B2

反応ノート

読み込み中…