Pyrrolidine → (2S)-2-hydroxy-1-(1-pyrrolidinyl)-1-propanone

反応式

[OH:1][C@@H:2]([CH3:7])[C:3](OC)=[O:4].[NH:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1>>[OH:1][C@@H:2]([CH3:7])[C:3]([N:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1)=[O:4]

参加物

反応物 2

HCID 31268Pyrrolidine

HCID 94386methyl (S)-lactate

生成物 1

HCID 11051776(2S)-2-hydroxy-1-(1-pyrrolidinyl)-1-propanone収率 99.7%

実験手順

(S)-Methyl 2-hydroxypropanoate (30.0 g, 288 mmol) and pyrrolidine (22.5 g, 317 mmol) were stirred at RT for 3 d. The crude product was purified by passing through a SiO2 plug eluting with 80% EtOAc/hexane to afford 41.1 g (99.6%) (S)-2-hydroxy-1-(pyrrolidin-1-yl)propan-1-one (108).

後処理

customThe crude product was purified
washeluting with 80% EtOAc/hexane

出典と根拠

ORDレコード: ord-fe1ba449fc2b4abe88e5ee84c5516a65
出典データセット: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09133187B2

反応ノート

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