Water → HCID 59579909、化合物
反応式
[OH-].[Na+].[Cl:3][C:4]1[N:8]([C:9]2[N:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[N:7]=[CH:6][C:5]=1[C:15]([O:17]CC)=[O:16].O>CCO>[Cl:3][C:4]1[N:8]([C:9]2[N:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[N:7]=[CH:6][C:5]=1[C:15]([OH:17])=[O:16]参加物
5
実験手順
A 1 N aqueous sodium hydroxide solution (2.0 mL) is added to a suspension of ethyl 5-chloro-1-pyrimidin-2-yl-1H-pyrazole-4-carboxylate (250 mg, 1.11 mmol) in 5.0 mL of EtOH. The reaction mixture is stirred at RT for 1 h. Water is added, and the solution is washed with EtOAc. The aqueous layer is cooled to 0° C. and acidified to pH=2-3 with conc. HCl. The precipitated solid is collected by vacuum filtration and dried in vacuo to give the title compound as a white solid.
後処理
- washthe solution is washed with EtOAc
- temperatureThe aqueous layer is cooled to 0° C.
- filtrationThe precipitated solid is collected by vacuum filtration
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-d0bcc064cd7d40eabdbff48f7a539541
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09133204B2
反応ノート
読み込み中…