Sodium Hydroxide → 5-Benzyl-1,3-dimethyl-1H-pyrazole-4-carboxylic acid

HRID 2279642ノート

反応式

HRID 2279642 の反応式
[OH-].[Na+].C[O:4][C:5]([C:7]1[C:8]([CH3:20])=[N:9][N:10]([CH3:19])[C:11]=1[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:6]>CO>[CH2:12]([C:11]1[N:10]([CH3:19])[N:9]=[C:8]([CH3:20])[C:7]=1[C:5]([OH:6])=[O:4])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 154462275-benzyl-1,3-dimethyl-1H-pyrazole-4-carboxylic acid methyl ester

生成物 1

HCID 595799845-Benzyl-1,3-dimethyl-1H-pyrazole-4-carboxylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
50 °C

実験手順

NaOH (10 N, 7 mL) is added to a solution of 5-benzyl-1,3-dimethyl-1H-pyrazole-4-carboxylic acid methyl ester (680 mg, 2.78 mmol) in MeOH (10 mL) at RT. The mixture is heated to 50° C. for 4 h. The solvent is removed to dryness. H2O is added and pH is adjusted to 5 using aq. HCl. The solid is filtered and dried to give the title compound.

後処理

  1. customThe solvent is removed to dryness
  2. additionH2O is added
  3. filtrationThe solid is filtered
  4. customdried

出典と根拠

ORDレコード
ord-addbbf4343454f61b3a7044fb462cd9f
出典データセット
uspto-grants-2015_09
特許番号
US09133204B2

反応ノート

読み込み中…