Sodium Hydroxide → HCID 59580006、化合物

HRID 2279651ノート

反応式

HRID 2279651 の反応式
C([O:3][C:4]([C:6]1[S:10][C:9]([C:11]2[N:16]=[CH:15][CH:14]=[CH:13][N:12]=2)=[N:8][C:7]=1[C:17]([F:20])([F:19])[F:18])=[O:5])C.[OH-].[Na+]>CO.O>[N:16]1[CH:15]=[CH:14][CH:13]=[N:12][C:11]=1[C:9]1[S:10][C:6]([C:4]([OH:5])=[O:3])=[C:7]([C:17]([F:19])([F:20])[F:18])[N:8]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 59579876HCID 59579876、化合物

生成物 1

HCID 59580006HCID 59580006、化合物

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

反応条件

温度
50 °C

実験手順

A mixture of 2-pyrimidin-2-yl-4-trifluoromethyl-thiazole-5-carboxylic acid ethyl ester (1.6 g) and sodium hydroxide (1.2 g) in MeOH (10 mL) and water (3 mL) is heated at 50° C. with stirring for 30 min, cooled and evaporated. The residue is acidified with citric acid solution and extracted with EtOAc six times. The combined extracts are washed once with brine, dried over Na2SO4 and concentrated to give the title compound as a solid.

後処理

  1. temperaturecooled
  2. customevaporated
  3. extractionextracted with EtOAc six times
  4. washThe combined extracts are washed once with brine
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-02dfca3419d748ae88c90c15391661e5
出典データセット
uspto-grants-2015_09
特許番号
US09133204B2

反応ノート

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