Sodium Hydroxide → N-Boc-amino-4-methylthiazole-5-carboxylic acid
反応式
C([O:3][C:4]([C:6]1[S:10][C:9]([NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])=[N:8][C:7]=1[CH3:19])=[O:5])C.[OH-].[Na+]>CO>[C:15]([O:14][C:12]([NH:11][C:9]1[S:10][C:6]([C:4]([OH:5])=[O:3])=[C:7]([CH3:19])[N:8]=1)=[O:13])([CH3:18])([CH3:16])[CH3:17]参加物
4
反応条件
- 温度
- 50 °C
実験手順
A mixture of 2-tert-butoxycarbonylamino-4-methyl-thiazole-5-carboxylic acid ethyl ester (4.3 g) and sodium hydroxide (10 N, 2.5 mL) in MeOH (80 mL) is heated at 50° C. overnight. The mixture is cooled, concentrated in vacuo, diluted with water and acidified to pH 4-5 with 2 N HCl. The solid is collected by filtration and dried to give the title compound.
後処理
- temperatureThe mixture is cooled
- concentrationconcentrated in vacuo
- additiondiluted with water
- filtrationThe solid is collected by filtration
- customdried
出典と根拠
- ORDレコード
- ord-723571fde6124a608edfdafd49910edb
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09133204B2
反応ノート
読み込み中…