Oxalyl chloride → 1,3-BENZOTHIAZOLE-6-CARBONYL CHLORIDE
反応式
[S:1]1[C:5]2[CH:6]=[C:7]([C:10]([OH:12])=O)[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.C(Cl)(=O)C([Cl:16])=O>C(Cl)Cl.CN(C)C=O>[S:1]1[C:5]2[CH:6]=[C:7]([C:10]([Cl:16])=[O:12])[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1参加物
5
反応条件
- 温度
- 30 °C
実験手順
Under a nitrogen atmosphere, benzothiazole-6-carboxylic acid (1.014 g, 5.6 mmol) was dissolved in methylene chloride (25 mL). Five drops of N,N-dimethylforamide was added. Oxalyl chloride (0.5 mL, 5.6 mmol) was slowly added. After 2 hrs, the reaction was heated to 30° C. for 16 hrs. The reaction was concentrated in vacuo to yield benzothiazole-6-carbonyl chloride (19A) (1.665 g, quant., light yellow powder).
後処理
- concentrationThe reaction was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-aa27aa48828f41f398d914f3d798210f
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09138427B2
反応ノート
読み込み中…