Hydrochloric Acid → (2R)-2-acetamido-3-methoxypropanoic acid

HRID 2280359ノート

反応式

HRID 2280359 の反応式
[C:1]([NH:4][CH:5]([C:9]([OH:11])=[O:10])[CH2:6][O:7][CH3:8])(=[O:3])[CH3:2].[OH-].[Na+].Cl>O>[C:1]([NH:4][C@H:5]([CH2:6][O:7][CH3:8])[C:9]([OH:11])=[O:10])(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 189180482-Acetamido-3-methoxypropanoic acid

生成物 1

HCID 10558933(2R)-2-acetamido-3-methoxypropanoic acid収率 50%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
25 °C

実験手順

In a vessel, equipped with a magnetic stirrer and pH controller, N-acetyl-O-methyl-D,L-serine (3 g) was dissolved in demineralized water (30 mL) and the pH was adjusted to 7.5-8.0 with 5N sodium hydroxide solution. Acylase I from Porcine Kidney (EC: 3.5.1.14) (50 mg) was added and the solution maintained at 25° C. under mild agitation overnight. The pH was adjusted to 2.7 with concentrated HCl and the aqueous solution injected onto Dowex™ 50WX4-50 ion exchange resin (50 mL) conditioned at pH 3.8. The resulting material was eluted with water at pH 2.4. The aqueous solution thereby obtained was then evaporated to dryness under vacuum to afford the title compound (1.5 g, 50%) as an off-white solid.

後処理

  1. customIn a vessel, equipped with a magnetic stirrer
  2. additionAcylase I from Porcine Kidney (EC: 3.5.1.14) (50 mg) was added
  3. washThe resulting material was eluted with water at pH 2.4
  4. customThe aqueous solution thereby obtained
  5. customwas then evaporated to dryness under vacuum

出典と根拠

ORDレコード
ord-d3a07d20d77c47be9b81a14f76a28436
出典データセット
uspto-grants-2015_09
特許番号
US09139513B2

反応ノート

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