Thionyl Chloride → HCID 12018889、化合物

HRID 2280423ノート

反応式

HRID 2280423 の反応式
[Si:1]([O:8][CH2:9][C:10]1[CH:18]=[CH:17][C:13]([C:14](O)=[O:15])=[CH:12][CH:11]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].S(Cl)([Cl:21])=O>>[Si:1]([O:8][CH2:9][C:10]1[CH:18]=[CH:17][C:13]([C:14]([Cl:21])=[O:15])=[CH:12][CH:11]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 11747545Benzoic acid, 4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-

生成物 1

HCID 12018889HCID 12018889、化合物

反応条件

温度
80 °C

実験手順

4-[[t-Butyl(dimethyl)silyl]oxymethyl]benzoic acid (1.44 g) was suspended in thionyl chloride and the mixture was heated to 80° C. for 45 minutes. The resulting solution was concentrated in vacuo. Residual thionyl chloride and HCl were removed by subsequent concentration from toluene (twice). The crude residue was carried on to the next reaction step without purification.

後処理

  1. concentrationThe resulting solution was concentrated in vacuo
  2. customResidual thionyl chloride and HCl were removed by subsequent concentration from toluene (twice)
  3. customThe crude residue was carried on to the next reaction step without purification

出典と根拠

ORDレコード
ord-61798e268da144de97cf087135e1e13b
出典データセット
uspto-grants-2015_09
特許番号
US09139532B2

反応ノート

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