(4'-(Benzyloxy)-2,2',6'-trimethylbiphenyl-3-yl)methanol → 3'-(Hydroxymethyl)-2,2',6-trimethylbiphenyl-4-ol

HRID 2280656ノート

反応式

HRID 2280656 の反応式
C([O:8][C:9]1[CH:14]=[C:13]([CH3:15])[C:12]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][OH:23])[C:17]=2[CH3:24])=[C:11]([CH3:25])[CH:10]=1)C1C=CC=CC=1>CO.[Pd]>[OH:23][CH2:22][C:18]1[C:17]([CH3:24])=[C:16]([C:12]2[C:11]([CH3:25])=[CH:10][C:9]([OH:8])=[CH:14][C:13]=2[CH3:15])[CH:21]=[CH:20][CH:19]=1

参加物

4

反応物 1

HCID 89701782(4'-(Benzyloxy)-2,2',6'-trimethylbiphenyl-3-yl)methanol

生成物 1

HCID 683329993'-(Hydroxymethyl)-2,2',6-trimethylbiphenyl-4-ol収率 92.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

(4′-(Benzyloxy)-2,2′,6′-trimethylbiphenyl-3-yl)methanol 12c (190 mg, 0.57 mmol) was dissolved in 5 mL of methanol, followed by addition of Pd/C (20 mg, 10%) under hydrogen atomosphere. The reaction solution was stirred for 12 hours. The resulting solution was filtered, and the filtrate was concentrated under reduced pressure to obtain the crude title compound 3′-(hydroxymethyl)-2,2′,6-trimethylbiphenyl-4-ol 12d (128 mg) as a yellow solid, which was used directly in the next step without further purification.

後処理

  1. filtrationThe resulting solution was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-844baf1510b544ce904b4cae442b56e6
出典データセット
uspto-grants-2015_09
特許番号
US09139548B2

反応ノート

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