Sodium Hydroxide → 2-(2-Chloro-2-propenyl)-5-(4-chlorobenzyl)-2-methylcyclopentanone

HRID 2283162ノート

反応式

HRID 2283162 の反応式
COC([C:5]1([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)[CH2:9][CH2:8][C:7]([CH2:11][C:12]([Cl:14])=[CH2:13])([CH3:10])[C:6]1=[O:15])=O.[OH-].[Na+]>CC(O)C.O>[Cl:14][C:12](=[CH2:13])[CH2:11][C:7]1([CH3:10])[CH2:8][CH2:9][CH:5]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)[C:6]1=[O:15]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 86670684HCID 86670684、化合物2 回

生成物 1

HCID 866706832-(2-Chloro-2-propenyl)-5-(4-chlorobenzyl)-2-methylcyclopentanone

試薬・触媒・溶媒 2

HCID 962Water溶媒2 回HCID 3776Isopropanol溶媒

実験手順

3-(2-Chloro-2-propenyl)-1-(4-chlorobenzyl)-3-methyl-2-oxocyclopentane carboxylic acid methyl ester (Compound (XIII), R1=(Rb)Xbnb=CH2CCl═CH2, R2═CH3) (2.90 g, 8.16 mmol) was dissolved in i-PrOH (5 ml), and then an aqueous solution of NaOH (0.65 g, 16.3 mmol) dissolved in water (5.4 ml) was added, and stirring under reflux was conducted for 2.5 hours. Water (50 ml) was added, and extraction with hexane (50 ml×2) was conducted. The organic layer was dried over anhydrous sodium sulfate, and concentrated to obtain the desired substance

後処理

  1. additionwas added
  2. temperatureunder reflux
  3. extractionextraction with hexane (50 ml×2)
  4. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  5. concentrationconcentrated
  6. customto obtain the desired substance

出典と根拠

ORDレコード
ord-40650e4fe9094dfd9cee22e1e8f76c52
出典データセット
uspto-grants-2015_09
特許番号
US09145351B2

反応ノート

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