2-[[(E)-2-(4-Benzofuran-2-ylphenyl)ethenyl]sulfonylamino]benzenesulfonamide → 2-[2-(4-Benzofuran-2-ylphenyl)ethylsulfonylamino]benzenesulfonamide

HRID 2283258ノート

反応式

HRID 2283258 の反応式
[O:1]1[C:6]2=[CH:7][CH:8]=[CH:9][C:5]2=[CH:4][CH:3]=[C:2]1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1/[CH:16]=[CH:17]/[S:18]([NH:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[S:28]([NH2:31])(=[O:30])=[O:29])(=[O:20])=[O:19].[H][H]>C(OCC)(=O)C.[Pd]>[O:1]1[C:6]2=[CH:7][CH:8]=[CH:9][C:5]2=[CH:4][CH:3]=[C:2]1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH2:16][CH2:17][S:18]([NH:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[S:28]([NH2:31])(=[O:30])=[O:29])(=[O:20])=[O:19]

参加物

5

反応物 2

HCID 866319992-[[(E)-2-(4-Benzofuran-2-ylphenyl)ethenyl]sulfonylamino]benzenesulfonamideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 687852732-[2-(4-Benzofuran-2-ylphenyl)ethylsulfonylamino]benzenesulfonamide収率 28%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

2-[[(E)-2-(4-Benzofuran-2-ylphenyl)ethenyl]sulfonylamino]benzenesulfonamide (Example 3, 43 mg, 95 μmol) was dissolved in ethyl acetate (5 ml) and subjected to the H-cube (1 ml/min, full hydrogen. 10% Pd/C). The material obtained was purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer) to give the title compound (12 mg, 28%) as a white solid. The compound of Example 2 was also obtained.

後処理

  1. customThe material obtained
  2. customwas purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer)

出典と根拠

ORDレコード
ord-9216dfc5c0b14344a5c91d85d8844b31
出典データセット
uspto-grants-2015_09
特許番号
US09145380B2

反応ノート

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