Water → (E)-2-(4-benzofuran-2-ylphenyl)ethenesulfonic acid

HRID 2283261

反応式

HRID 2283261 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[S:10]([O:13]CC)(=[O:12])=[O:11])=[CH:4][CH:3]=1.[O:16]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[CH:18]=[C:17]1B(O)O.C(=O)([O-])[O-].[Na+].[Na+].O>CN(C=O)C.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[O:16]1[C:17]2=[CH:18][CH:19]=[CH:24][C:23]2=[CH:22][CH:21]=[C:20]1[C:4]1[CH:3]=[CH:2][CH:7]=[CH:6][C:5]=1/[CH:8]=[CH:9]/[S:10]([OH:13])(=[O:11])=[O:12]

参加物

7

反応物 4

HCID 962WaterHCID 10340Sodium CarbonateHCID 2776266Benzo[b]furan-2-boronic acidHCID 866320021-Bromo-4-[(E)-2-ethoxysulfonylethenyl]benzene

生成物 1

HCID 86632001(E)-2-(4-benzofuran-2-ylphenyl)ethenesulfonic acid

試薬・触媒・溶媒 2

HCID 178418397HCID 178418397、化合物触媒HCID 6228Dimethylformamide溶媒

反応条件

温度
90 °C

実験手順

1-Bromo-4-[(E)-2-ethoxysulfonylethenyl]benzene (1.0 g, 3.4 mmol) and benzofuran-2-boronic acid (0.61 g, 3.7 mmol) were dissolved in DMF (20 mL). Sodium carbonate (2M, 10 mL) and tetrakis(triphenylphosphine)palladium(0) (200 mg, 0.17 mmol) were added and the resulting mixture was stirred under argon at 90° C. for 12 h. Water was added to the mixture and the resulting precipitate was collected, washed with water and dried to give the product as a sodium salt which was used in the next step without further purification (0.38 g, 35%).

後処理

  1. customthe resulting precipitate was collected
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-6f7934a3cfb64b659960316d4ee6f006
出典データセット
uspto-grants-2015_09
特許番号
US09145380B2

関連ノート

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