2-Aminobenzenesulfonamide → HCID 57750902、化合物

HRID 2283292ノート

反応式

HRID 2283292 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9].[F:12][C:13]1[C:18]([F:19])=[CH:17][CH:16]=[CH:15][C:14]=1[S:20](Cl)(=[O:22])=[O:21]>N1C=CC=CC=1>[F:12][C:13]1[C:18]([F:19])=[CH:17][CH:16]=[CH:15][C:14]=1[S:20]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8](=[O:9])(=[O:10])[NH2:11])(=[O:22])=[O:21]

参加物

4

反応物 2

HCID 728942-AminobenzenesulfonamideHCID 218690652,3-Difluorobenzene-1-sulfonyl chloride

生成物 1

HCID 57750902HCID 57750902、化合物収率 58%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

2-Aminobenzenesulfonamide (26 mg, 0.15 mmol) was dissolved in pyridine (1 ml) and 2,3-difluorophenylsulfonyl chloride (19 μl, 0.15 mmol) was added and the reaction stirred overnight. The solvent was removed in vacuo and the residue was purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer) to give the title compound (30 mg, 58%).

後処理

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer)

出典と根拠

ORDレコード
ord-9548669f86c64afbbc317c705e043bf3
出典データセット
uspto-grants-2015_09
特許番号
US09145380B2

反応ノート

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