2,3-Difluorobenzene-1-sulfonyl chloride → HCID 57751038、化合物

HRID 2283293ノート

反応式

HRID 2283293 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[S:9]([NH2:12])(=[O:11])=[O:10].[F:13][C:14]1[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=1[S:21](Cl)(=[O:23])=[O:22]>N1C=CC=CC=1>[F:13][C:14]1[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=1[S:21]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[S:9](=[O:11])(=[O:10])[NH2:12])(=[O:23])=[O:22]

参加物

4

反応物 2

HCID 218690652,3-Difluorobenzene-1-sulfonyl chlorideHCID 224818252-Amino-5-fluorobenzenesulfonamide

生成物 1

HCID 57751038HCID 57751038、化合物収率 46%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

2-Amino-5-fluorobenzenesulfonamide (29 mg, 0.15 mmol) was dissolved in pyridine (1 ml) and 2,3-difluorophenylsulfonyl chloride (19 μl, 0.15 mmol) was added and the reaction stirred overnight. The solvent was removed in vacuo and the residue was purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer) to give the title compound (25 mg, 46%).

後処理

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified by preparative HPLC (XTerra MS C8 column, acetonitrile/ammonium acetate buffer)

出典と根拠

ORDレコード
ord-90068a253ac7493f8ac7190cdebc4c47
出典データセット
uspto-grants-2015_09
特許番号
US09145380B2

反応ノート

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