Water → HCID 89544754、化合物

HRID 2283390ノート

反応式

HRID 2283390 の反応式
[Cl:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])=[C:6]([F:16])[C:5]([CH:17](Br)Br)=[CH:4][CH:3]=1.C([OH:23])(C)C.O>[N+]([O-])([O-])=O.[Ag+].ClCCl>[C:8]([C:7]1[C:6]([F:16])=[C:5]([CH:4]=[CH:3][C:2]=1[Cl:1])[CH:17]=[O:23])(=[O:9])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

参加物

6

反応物 3

HCID 962WaterHCID 3776IsopropanolHCID 89544515HCID 89544515、化合物

生成物 1

HCID 89544754HCID 89544754、化合物収率 90%

試薬・触媒・溶媒 2

HCID 24470Silver Nitrate触媒HCID 6344Dichloromethane溶媒

実験手順

Step 4 A mixture of (6-chloro-3-dibromomethyl-2-fluoro-phenyl)-phenyl-methanone (582 mg, 1.38 mmol), silver nitrate (469 mg, 2.76 mmol), isopropanol (10 ml) and water (2 ml) was stirred at room temperature overnight. Dichloromethane was added and the mixture was filtered under suction washing with isopropanol. The organic liquors were concentrated then purified by silica chromatography eluting with 0-20% ethyl acetate/petroleum ether furnishing 3-benzoyl-4-chloro-2-fluoro-benzaldehyde (222 mg oil, 90% clean). Analytical data as above

後処理

  1. filtrationthe mixture was filtered under suction
  2. washwashing with isopropanol
  3. concentrationThe organic liquors were concentrated
  4. customthen purified by silica chromatography
  5. washeluting with 0-20% ethyl acetate/petroleum ether

出典と根拠

ORDレコード
ord-7fa7af75ac5d4723aaa094068a7416e3
出典データセット
uspto-grants-2015_09
特許番号
US09145354B2

反応ノート

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