ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Cyclopropylamine → HCID 90308860、化合物

HRID 2283671
ノート
印刷プレビュー

反応式

HRID 2283671 の反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([O-:10])=O)=[N:6][CH:7]=1.Cl[C:12]1[N:13]=[C:14]([S:23][CH3:24])[N:15]=[N:16][C:17]=1[C:18]([O:20][CH2:21][CH3:22])=[O:19].[CH:25]1([NH2:28])[CH2:27][CH2:26]1.C(N(C(C)C)CC)(C)C.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>CS(C)=O.C(OCC)(=O)C>[CH:25]1([NH:28][C:8]([C:5]2[N:6]=[CH:7][C:2]([NH:1][C:12]3[N:13]=[C:14]([S:23][CH3:24])[N:15]=[N:16][C:17]=3[C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:3][CH:4]=2)=[O:10])[CH2:27][CH2:26]1
参加物実験手順後処理出典と根拠反応ノート

参加物

8

反応物 5

HCID 69828CyclopropylamineHCID 81531DiisopropylethylamineHCID 7023052HCID 7023052、化合物HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 11557703Ethyl 5-Chloro-3-(Methylthio)-1,2,4-Triazine-6-Carboxylate

生成物 1

HCID 90308860
HCID 90308860、化合物

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 8857Ethyl Acetate溶媒

実験手順

5-Aminopicolinate (44 mg) was added to a solution of ethyl 5-chloro-3-(methylthio)-1,2,4-triazine-6-carboxylate (70 mg) in dimethylsulfoxide (1.5 ml), and the reaction solution was stirred at room temperature for 10 minutes. Thereafter, cyclopropylamine (0.017 ml), diisopropylethylamine (0.079 ml), and HATU (125 mg) were successively added, and the reaction solution was stirred at room temperature overnight. The reaction solution was diluted with ethyl acetate, and washed successively with an aqueous sodium bicarbonate solution and a saturated saline solution. After drying over anhydrous sodium sulfate, the solvent was evaporated under vacuum. The resultant residue was purified by column chromatography on silica gel (developing solvent:hexane/ethyl acetate) to obtain ethyl 5-(6-(cyclopropylcarbamoyl)pyridin-3-ylamino)-3-(methylthio)-1,2,4-triazine-6-carboxylate.

後処理

  1. stirringthe reaction solution was stirred at room temperature overnight
  2. washwashed successively with an aqueous sodium bicarbonate solution
  3. dry with materialAfter drying over anhydrous sodium sulfate
  4. customthe solvent was evaporated under vacuum
  5. customThe resultant residue was purified by column chromatography on silica gel (developing solvent:hexane/ethyl acetate)

出典と根拠

ORDレコード
ord-6e95b51751204f429e464b8ac5dc88a8
出典データセット
uspto-grants-2015_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09145414B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート