Sulfuric Acid → HCID 90308837、化合物
反応式
S(=O)(=O)(O)O.[Br:6][C:7]1[CH:8]=[C:9]([N+:16]([O-:18])=[O:17])[CH:10]=[C:11]2[C:15]=1[NH:14][N:13]=[CH:12]2>CC(O)(C)C>[Br:6][C:7]1[C:15]2[C:11](=[CH:12][N:13]([C:11]([CH3:15])([CH3:12])[CH3:10])[N:14]=2)[CH:10]=[C:9]([N+:16]([O-:18])=[O:17])[CH:8]=1参加物
4
実験手順
2-Methyl-2-propanol (5 mL) and concentrated sulfuric acid (0.1 mL) were added to 7-bromo-5-nitro-1H-indazole (484 mg), and the reaction solution was allowed to react in a microwave reactor at 100° C. for 1 hour. After dilution with ethyl acetate, the reaction solution was washed successively with an aqueous sodium bicarbonate solution and a saturated saline solution. After drying over anhydrous sodium sulfate, the solvent was evaporated under vacuum to obtain 7-bromo-2-(tert-butyl)-5-nitro-2H-indazole as a light yellow solid.