HCID 57717605、化合物 → HCID 66959065、化合物

反応式

C([N:8]1[C:20]([CH3:21])=[C:19]2[C:10]([C:11]([NH2:22])=[N:12][C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=32)=[N:9]1)C1C=CC=CC=1>Br.C(O)(=O)C>[CH3:21][C:20]1[NH:8][N:9]=[C:10]2[C:19]=1[C:18]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[N:12]=[C:11]2[NH2:22]

参加物

反応条件

温度: 140 °C

実験手順

A poly(tetrafluoroethylene)-lined steel pressure vessel containing a solution of 2-benzyl-1-methyl-2H-pyrazolo[3,4-c]quinolin-4-amine (prepared as described in Example 36, 0.8821 g, 3.06 mmol) in anhydrous hydrogen bromide in acetic acid (10 mL) was heated in a 140° C. oven for 17 hours. The vessel was allowed to cool to room temperature. A solid formed that was isolated by filtration and washed with water to yield 1-methyl-2H-pyrazolo[3,4-c]quinolin-4-amine that was used in the next step.