Hydrochloric Acid → Hydrochloric Acid

HRID 2284688ノート

反応式

HRID 2284688 の反応式
[N+:1]([C:4]1[C:5]([NH:10][CH2:11][CH2:12][CH2:13][NH:14]C(=O)OC(C)(C)C)=[N:6][CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[ClH:22].C(OC(C)C)(C)C>O1CCOCC1.O>[N+:1]([C:4]1[C:5]([NH:10][CH2:11][CH2:12][CH2:13][NH2:14])=[N:6][CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[ClH:22]

参加物

7

反応物 3

HCID 313Hydrochloric AcidHCID 7914Diisopropyl EtherHCID 70335437Tert-butyl (3-((3-nitropyridin-2-yl)amino)propyl)carbamate

生成物 2

HCID 313Hydrochloric AcidHCID 24710080HCID 24710080、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 312751,4-Dioxane溶媒

実験手順

To tert-butyl (3-((3-nitropyridin-2-yl)amino)propyl)carbamate (C42, 53 mg), a 4.0 mol/L solution of hydrochloric acid in dioxane (2 mL) and water (100 μL) were added at room temperature, and the mixture was stirred at the same temperature for 1 hour. To the reaction mixture, diisopropyl ether were added, the solvent was removed by decantation, and then the residue was dried under reduced pressure to obtain N1-(3-nitropyridin-2-yl)propane-1,3-diamine (C43) hydrochloride (113 mg).

後処理

  1. customthe solvent was removed by decantation
  2. customthe residue was dried under reduced pressure

出典と根拠

ORDレコード
ord-3be6e219e4684fb4921419e01949fbc2
出典データセット
uspto-grants-2015_09
特許番号
US09145415B2

反応ノート

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