Hydrogen Bromide → 1,2,3,4-Tetrahydroisoquinolin-6-ol
反応式
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:7][CH2:6]2.Br>>[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:7][CH2:6]2参加物
3
実験手順
Combine 6-Methoxy-1,2,3,4-tetrahydro-isoquinoline (5.0, 20.5 mmol) and 48% HBr(aq), 20 ml at room temperature. After the reaction refluxes for 24 hours, cool the reaction to room temperature and concentrate under reduced pressure. Triturate with ethyl acetate and filter to afford 5.5 g, 20.5 mmol (99% yield) of the title compound as a tan solid: 1H NMR (500 MHz, DMSO); 2.8-2.9 (2H, m), 3.3-3.4 (2H, m), 4.1 (2H, s), 6.5-6.7 (2H, m), 6.9-7.1 (1H, m), 8.8-9.0 (2H, br s), 9.4-9.5 (1H, s).
後処理
- customat room temperature
- temperaturecool
- customthe reaction to room temperature
- concentrationconcentrate under reduced pressure
- customTriturate with ethyl acetate
- filtrationfilter
出典と根拠
- ORDレコード
- ord-071bb065474646f98dbb78bad8de9ab9
- 出典データセット
- uspto-grants-2009_07
- 特許番号
- US07560463B2
反応ノート
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