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Ethyl Acetate → 2-(5-(2-((3-Fluorophenyl)amino)-4-(propylamino)pyrimidin-5-yl)isoxazol-3-yl)ethanol

HRID 2284797
ノート
印刷プレビュー

反応式

HRID 2284797 の反応式
[Si]([O:8][CH2:9][CH2:10][C:11]1[CH:15]=[C:14]([C:16]2[C:17]([NH:30][CH2:31][CH2:32][CH3:33])=[N:18][C:19]([NH:22][C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[CH:24]=3)=[N:20][CH:21]=2)[O:13][N:12]=1)(C(C)(C)C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC.C(=O)([O-])O.[Na+].C(OCC)(=O)C>O1CCCC1>[F:29][C:25]1[CH:24]=[C:23]([NH:22][C:19]2[N:18]=[C:17]([NH:30][CH2:31][CH2:32][CH3:33])[C:16]([C:14]3[O:13][N:12]=[C:11]([CH2:10][CH2:9][OH:8])[CH:15]=3)=[CH:21][N:20]=2)[CH:28]=[CH:27][CH:26]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 8857Ethyl AcetateHCID 516892Sodium BicarbonateHCID 2724141Tetrabutylammonium FluorideHCID 1317335355-(3-(2-((tert-butyldimethylsilyl)oxy)ethyl)isoxazol-5-yl)-N2-(3-fluorophenyl)-N4-propylpyrimidine-2,4-diamine

生成物 1

HCID 900517642-(5-(2-((3-Fluorophenyl)amino)-4-(propylamino)pyrimidin-5-yl)isoxazol-3-yl)ethanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a solution of 5-(3-(2-((tert-butyldimethylsilyl)oxy)ethyl)isoxazol-5-yl)-N2-(3-fluorophenyl)-N4-propylpyrimidine-2,4-diamine (S4, 22 mg) in tetrahydrofuran (1 mL), a 1.0 mol/L solution of tetrabutylammonium fluoride in tetrahydrofuran (69 μL) was added under ice cooling, and the mixture was stirred at room temperature for 3 hours. To the reaction mixture, saturated aqueous sodium hydrogencarbonate and ethyl acetate were added. The organic layer was separated, washed successively with water and saturated aqueous sodium chloride, and then dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (eluent, 70 to 5% hexane in ethyl acetate) to obtain 2-(5-(2-((3-fluorophenyl)amino)-4-(propylamino)pyrimidin-5-yl)isoxazol-3-yl)ethanol (S5, 5.3 mg) as white solid.

後処理

  1. customThe organic layer was separated
  2. washwashed successively with water and saturated aqueous sodium chloride
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customthe solvent was evaporated under reduced pressure
  5. customThe obtained residue was purified by silica gel column chromatography (eluent, 70 to 5% hexane in ethyl acetate)

出典と根拠

ORDレコード
ord-31ac2e4c76614e919640327a2db52666
出典データセット
uspto-grants-2015_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09145415B2

反応ノート

読み込み中…

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