Ozone → 2,2-Dimethyl-3-(2-oxopropyl)cyclopropanecarbaldehyde
反応式
CN(C)C=[CH:4][CH:5]1[CH:7]([CH2:8][C:9](=[O:11])[CH3:10])[C:6]1([CH3:13])[CH3:12].[O:15]=[O+][O-]>C(Cl)Cl>[CH3:12][C:6]1([CH3:13])[CH:7]([CH2:8][C:9](=[O:11])[CH3:10])[CH:5]1[CH:4]=[O:15]参加物
4
実験手順
To a solution 2.4 g of 1-(3-(2-(dimethylamino)ethenyl)-2,2-dimethylcyclopropyl)-2-propanone, the product of Embodiment I, in 50 ml of methylene chloride was added 0.6 g of ozone over 20 min at -80° C. The resulting mixture was purged with air and 1.5 g of triethylamine was added dropwise at -30° C. The resulting mixture, after stirring and warming to room temperature, had a negative test to starch iodide paper. The reaction mixture was poured into 25 ml 1 N hydrochloride acid solution. The resulting mixture separated into two phases and the methylene chloride phase was washed with water, dried with MgSO4, filtered and stripped to yield 1.6 g of the desired product as an oil.