Methyl iodide → HCID 20542067、化合物

反応式

[C:1](=[O:4])([O-])[O-].[K+].[K+].[C:7]([C:10]1[CH:11]=[CH:12][C:13]2[NH:19][C:18](=O)[CH:17]([CH3:21])[N:16]=[C:15]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[F:28])[C:14]=2[CH:29]=1)(=[O:9])[CH3:8].CI>CC(C)=O>[C:7]([C:10]1[CH:11]=[CH:12][C:13]2[N:19]([CH3:18])[C:1](=[O:4])[CH:17]([CH3:21])[N:16]=[C:15]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[F:28])[C:14]=2[CH:29]=1)(=[O:9])[CH3:8]

参加物

実験手順

7.15 g of potassium carbonate are added to a solution of 7.15 g (23.04 mmol) of 7-acetyl-5-(o-fluorophenyl)-1,3-dihydro-3-methyl-2H-1,4-benzodiazepin-2-one and 15 ml of methyl iodide in 300 ml of acetone and the mixture is stirred at room temperature for 21 hours. The insoluble material is filtered off and the solution is evaporated in vacuo. The residue is taken up in methylene chloride, washed with water, dried and evaporated. From cyclohexane there is obtained 7-acetyl-5-(o-fluorophenyl)-1,3-dihydro-1,3-dimethyl-2H-1,4-benzodiazepin-2-one of melting point 65°.