5-Chloro-2-hydroxybenzamide → 5-Chloro-2-[(6,7-dimethoxy-4-quinolyl)oxy]benzamide

HRID 228638

反応式

HRID 228638 の反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([OH:26])=[C:21]([CH:25]=1)[C:22]([NH2:24])=[O:23]>CN(C)C1C=CN=CC=1.ClC1C=CC=CC=1Cl>[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([O:26][C:2]2[C:11]3[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=3)[N:5]=[CH:4][CH:3]=2)=[C:21]([CH:25]=1)[C:22]([NH2:24])=[O:23]

参加物

5

反応物 2

HCID 3480945-Chloro-2-hydroxybenzamideHCID 4596104-Chloro-6,7-dimethoxyquinoline

生成物 1

HCID 577563635-Chloro-2-[(6,7-dimethoxy-4-quinolyl)oxy]benzamide収率 165.2%

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 72391,2-Dichlorobenzene溶媒

反応条件

温度
120 °C

実験手順

4-Chloro-6,7-dimethoxyquinoline (100 mg), 5-chloro-2-hydroxybenzamide (343 mg), and 4-dimethylaminopyridine (244 mg) were suspended in o-dichlorobenzene (1 ml), and the suspension was stirred at 120° C. overnight. The reaction solution was cooled to room temperature, and the solvent was removed therefrom by distillation under the reduced pressure. The residue was purified by column chromatography using acetone-hexane to give the title compound (265 mg, yield 100%).

後処理

  1. temperatureThe reaction solution was cooled to room temperature
  2. customthe solvent was removed
  3. distillationby distillation under the reduced pressure
  4. customThe residue was purified by column chromatography

出典と根拠

ORDレコード
ord-6953a73f3758450097841db38d2bbb6c
出典データセット
uspto-grants-2009_07
特許番号
US07560558B2

関連ノート

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