関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 5-Chloro-2-hydroxybenzamide | HCID 348094 | — |
| 反応物 | 4-Chloro-6,7-dimethoxyquinoline | HCID 459610 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | 1,2-Dichlorobenzene | HCID 7239 | — |
| 生成物 | 5-Chloro-2-[(6,7-dimethoxy-4-quinolyl)oxy]benzamide | HCID 57756363 | 165.2% |
反応手順
4-Chloro-6,7-dimethoxyquinoline (100 mg), 5-chloro-2-hydroxybenzamide (343 mg), and 4-dimethylaminopyridine (244 mg) were suspended in o-dichlorobenzene (1 ml), and the suspension was stirred at 120° C. overnight. The reaction solution was cooled to room temperature, and the solvent was removed therefrom by distillation under the reduced pressure. The residue was purified by column chromatography using acetone-hexane to give the title compound (265 mg, yield 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07560558B2 |
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| 出典データセット | uspto-grants-2009_07 |
|---|
| ORD ID | ord-6953a73f3758450097841db38d2bbb6c |
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| 出典メモ | uspto-grants-2009_07 |
|---|
