反应详情

温度

120 °C

4-Chloro-6,7-dimethoxyquinoline (100 mg), 5-chloro-2-hydroxybenzamide (343 mg), and 4-dimethylaminopyridine (244 mg) were suspended in o-dichlorobenzene (1 ml), and the suspension was stirred at 120° C. overnight. The reaction solution was cooled to room temperature, and the solvent was removed therefrom by distillation under the reduced pressure. The residue was purified by column chromatography using acetone-hexane to give the title compound (265 mg, yield 100%).

1. temperatureThe reaction solution was cooled to room temperature
2. customthe solvent was removed
3. distillationby distillation under the reduced pressure
4. customThe residue was purified by column chromatography