Acetic Acid → 5-Bromo-2-(isopropylamino)pyrimidine
反応式
C(O)(=O)C.[CH:5]([NH:8][C:9]1[N:14]=[CH:13][CH:12]=[CH:11][N:10]=1)([CH3:7])[CH3:6].[Br:15]N1C(=O)CCC1=O>O>[CH:5]([NH:8][C:9]1[N:14]=[CH:13][C:12]([Br:15])=[CH:11][N:10]=1)([CH3:7])[CH3:6]参加物
5
実験手順
75 ml of acetic acid, 13.7 g (0.1 mole) of 2-isopropylamino-pyrimidine and 17.8 g (0.1 mole) of N-bromosuccinimide are poured into a 1 liter reaction vessel. The reaction mixture is stirred for 1 hour at room temperature and then poured into iced water. The resultant precipitate is filtered off, washed with water and dried. 20 g (yield 92%) of the title compound was obtained as a white powder melting at 90° C. Elemental analysis showed that the compound had the expected empirical formula of C7H10N3Br.
後処理
- filtrationThe resultant precipitate is filtered off
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-ad812181740b4e77a2477fb08ac2b748
- 出典データセット
- uspto-grants-1981_05
- 特許番号
- US04267181
反応ノート
読み込み中…