Hydrochloric Acid → HCID 54567480、化合物
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[C:9]([CH3:12])[CH:10]=[O:11])=[CH:4][CH:3]=1.[BH4-].[Na+].Cl>C(O)C.O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]=[C:9]([CH3:12])[CH2:10][OH:11])=[CH:6][CH:7]=1参加物
6
実験手順
To a solution of 113 g (0.69 mole) of 3-(4-fluorophenyl)-2-methyl-2-propen-1-al in 800 ml ethanol at 10° C. was added in portions 13.1 g (0.345 mole) of sodium borohydride. After the addition was complete, the reaction mixture was stirred at room temperature overnight. The mixture was cooled in an ice bath while 350 ml of 1 N hydrochloric acid was added dropwise to give a final pH of ~7. The mixture was diluted with 500 ml water and extracted three times with methylene chloride. The organic extracts were dried and concentrated and the residue distilled to give 56.1 g (49%) of colorless liquid, b.p. 68°-70° C. (0.15 mm).
後処理
- additionAfter the addition
- additionwas added dropwise
- customto give a final pH of ~7
- extractionextracted three times with methylene chloride
- customThe organic extracts were dried
- concentrationconcentrated
- distillationthe residue distilled
出典と根拠
- ORDレコード
- ord-8fda7342c02d4ae393d57ef268d3747f
- 出典データセット
- uspto-grants-1981_05
- 特許番号
- US04267190
反応ノート
読み込み中…