Water → HCID 13060090、化合物

HRID 2286721ノート

反応式

HRID 2286721 の反応式
[CH3:1][C:2]1[N:3]2[CH:9]=[C:8]([C:10](OC)=[O:11])[N:7]=[C:4]2[S:5][CH:6]=1.O>C1C=CC=CC=1.C1COCC1>[CH3:1][C:2]1[N:3]2[CH:9]=[C:8]([CH2:10][OH:11])[N:7]=[C:4]2[S:5][CH:6]=1

参加物

5

反応物 2

HCID 962WaterHCID 13060080Methyl 3-methylimidazo[2,1-b]thiazole-6-carboxylate

生成物 1

HCID 13060090HCID 13060090、化合物収率 98%

試薬・触媒・溶媒 2

HCID 241Benzene溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

100 ml of a 70% solution of NaAlH2 (CH3OCH2CH2O)2 in benzene are dropped at 25° into a suspension of 25 g of 3-methyl-6-carbomethoxy-imidazo-(2,1-b)thiazole, prepared as described in Example 8, in 250 ml of dry THF. The suspension is stirred for 2 hours at room temperature and thereafter 25 ml of water are slowly added. The suspension is then filtered and the filtrate concentrated to yield 21 g of 3-methyl-6-hydroxymethyl-imidazo-(2,1-b)thiazole; m.p. 155°-156° (methyl-ethyl-ketone).

後処理

  1. customprepared
  2. filtrationThe suspension is then filtered
  3. concentrationthe filtrate concentrated

出典と根拠

ORDレコード
ord-18a9eae5e9334253a9ba6dd40f87a8de
出典データセット
uspto-grants-1981_05
特許番号
US04267339

反応ノート

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