Thionyl Chloride → HCID 54281029、化合物

HRID 2287043ノート

反応式

HRID 2287043 の反応式
[CH3:1][C:2]([CH3:28])([CH:6]([N:16]([CH3:27])[S:17]([C:20]1[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=1)(=[O:19])=[O:18])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=1)[C:3](O)=[O:4].S(Cl)([Cl:31])=O>C1C=CC=CC=1>[CH3:1][C:2]([CH3:28])([CH:6]([N:16]([CH3:27])[S:17]([C:20]1[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=1)(=[O:19])=[O:18])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=1)[C:3]([Cl:31])=[O:4]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 540446942,2-dimethyl-4-(p-methoxyphenyl)-3-(N-methyl-p-toluenesulfonamido)butyric acid

生成物 1

HCID 54281029HCID 54281029、化合物

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A mixture of 283 g of 2,2-dimethyl-4-(p-methoxyphenyl)-3-(N-methyl-p-toluenesulfonamido)butyric acid, 1500 ml of dry benzene and 430 ml of thionyl chloride is boiled for 3 hours. After removal of volatile material by evaporation in vacuo, the residue is taken up in toluene and the solvent is evaporated in vacuo. This procedure is repeated twice whereafter crystallization of the initially oily product is accomplished by treatment with ether, melting point 110°-111° C.

後処理

  1. customAfter removal of volatile material
  2. customby evaporation in vacuo
  3. customthe solvent is evaporated in vacuo
  4. customThis procedure is repeated twice whereafter crystallization of the initially oily product

出典と根拠

ORDレコード
ord-e30474eeb11448ce991416ff3e8aa5ad
出典データセット
uspto-grants-1981_05
特許番号
US04268673

反応ノート

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