Bromine → 2-Bromo-5,6-dimethoxy-3-methylbenzene-1,4-diol

HRID 2287258ノート

反応式

HRID 2287258 の反応式
[Br:1]Br.[CH3:3][O:4][C:5]1[C:11]([O:12][CH3:13])=[C:10]([OH:14])[C:9]([CH3:15])=[CH:8][C:6]=1[OH:7]>C(Cl)(Cl)Cl>[CH3:3][O:4][C:5]1[C:11]([O:12][CH3:13])=[C:10]([OH:14])[C:9]([CH3:15])=[C:8]([Br:1])[C:6]=1[OH:7]

参加物

4

反応物 2

HCID 24408BromineHCID 111830272,3-Dimethoxy-5-methyl-1,4-benzenediol

生成物 1

HCID 127215532-Bromo-5,6-dimethoxy-3-methylbenzene-1,4-diol収率 100.7%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

A solution of 39.5 g of bromine in 70 ml of chloroform was added dropwise at about 5° C. to a solution of 46.0 g of 2,3-dimethoxy-5-methylhydroquinone in 500 ml of chloroform, under a nitrogen atmosphere. Stirring was continued at the same temperature for 3 hours, and then the reaction mixture was washed with water until the washings were colorless. The organic layer was dried over magnesium sulfate, and the solvent was distilled off under reduced pressure to provide 65.5 g of 2,3-dimethoxy-5-methyl-6-bromohydroquinone.

後処理

  1. washthe reaction mixture was washed with water until the washings
  2. dry with materialThe organic layer was dried over magnesium sulfate
  3. distillationthe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-883910633b4440c3995129d0be420811
出典データセット
uspto-grants-1981_05
特許番号
US04270003

反応ノート

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