Sodium Hydroxide → 5-Cyano-2-iodobenzoic acid

HRID 2287346ノート

反応式

HRID 2287346 の反応式
[OH-].[Na+].C[O:4][C:5](=[O:15])[C:6]1[CH:11]=[C:10]([C:12]#[N:13])[CH:9]=[CH:8][C:7]=1[I:14]>O.CO>[I:14][C:7]1[CH:8]=[CH:9][C:10]([C:12]#[N:13])=[CH:11][C:6]=1[C:5]([OH:15])=[O:4]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 23076822Methyl 5-cyano-2-iodobenzoate

生成物 1

HCID 220088225-Cyano-2-iodobenzoic acid収率 66.2%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

A solution of sodium hydroxide (0.44 g, 11 mmol) in water (10 ml) was added to 2-iodo-5-cyanobenzoic acid methyl ester (2.7 g, 9.4 mmol) in methanol. The mixture was stirred for 20 h, then most of the solvent was evaporated and the residue acidified with 2N hydrochloric acid. The resulting precipitate was filtered off and dried to give a white solid (1.7 g). MS (-CI) m /z 272 [M-H]+.

後処理

  1. custommost of the solvent was evaporated
  2. filtrationThe resulting precipitate was filtered off
  3. customdried

出典と根拠

ORDレコード
ord-2264b98e007e4a1daf8e6345d8bb6f21
出典データセット
uspto-grants-2000_07
特許番号
US06083952

反応ノート

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