4-benzyloxy-1-ethyl-2-methyl-1H-benzimidazole → 1H-Benzimidazol-4-ol, 1-ethyl-2-methyl-
反応式
C([O:8][C:9]1[C:17]2[N:16]=[C:15]([CH3:18])[N:14]([CH2:19][CH3:20])[C:13]=2[CH:12]=[CH:11][CH:10]=1)C1C=CC=CC=1>C(OCC)(=O)C.[Pd]>[CH2:19]([N:14]1[C:13]2[CH:12]=[CH:11][CH:10]=[C:9]([OH:8])[C:17]=2[N:16]=[C:15]1[CH3:18])[CH3:20]参加物
4
実験手順
To a solution of 4-benzyloxy-1-ethyl-2-methyl-1H-benzimidazole (370 mg) in ethyl acetate (3.7 ml) was added 10% palladium on carbon (18 mg), and the mixture was stirred for 5 hours at ambient temperature under hydrogen atmosphere. Insoluble material was filtered off, and the filtrate was concentrated in vacuo. The residue was crystallized with diisopropyl ether to give 1-ethyl-4-hydroxy-2-methyl-1H-benzimidazole (220 mg)
後処理
- filtrationInsoluble material was filtered off
- concentrationthe filtrate was concentrated in vacuo
- customThe residue was crystallized with diisopropyl ether
出典と根拠
- ORDレコード
- ord-75085759b9264bcbbe53595289868beb
- 出典データセット
- uspto-grants-2000_07
- 特許番号
- US06083961
反応ノート
読み込み中…