Water → HCID 15588674、化合物

HRID 2287586ノート

反応式

HRID 2287586 の反応式
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][C:8]1[C:16]2[O:15][C:14](=[O:17])[NH:13][C:12]=2[CH:11]=[CH:10][CH:9]=1.[C:18](=O)([O-])[O-].[K+].[K+].CI.O>CN(C)C=O>[CH3:18][N:13]1[C:12]2[CH:11]=[CH:10][CH:9]=[C:8]([O:7][CH:2]3[CH2:3][CH2:4][CH2:5][CH2:6][O:1]3)[C:16]=2[O:15][C:14]1=[O:17]

参加物

6

反応物 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 15588673HCID 15588673、化合物

生成物 1

HCID 15588674HCID 15588674、化合物収率 94.1%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a suspension of 7-(tetrahydropyran-2-yloxy)-2(3H)-benzoxazolone (300 mg) and potassium carbonate (529 mg) in dimethylformamide (3 ml) was added methyl iodide at ambient temperature, and the mixture was stirred for 3 hours under nitrogen atmosphere. Water was added to the reaction mixture, and the resulting precipitates were collected by filtration to give 3-methyl-7-(tetrahydropyran-2-yloxy)-2(3H)-benzoxazolone (299 mg).

後処理

  1. customthe resulting precipitates
  2. filtrationwere collected by filtration

出典と根拠

ORDレコード
ord-05f6cd4e581a44c28ad433d8ec7a748f
出典データセット
uspto-grants-2000_07
特許番号
US06083961

反応ノート

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