Malonic Acid → 4-[(E)-2-(4-pyridyl)vinyl]cinnamic acid

HRID 2287592ノート

反応式

HRID 2287592 の反応式
[N:1]1[CH:6]=[CH:5][C:4](/[CH:7]=[CH:8]/[C:9]2[CH:16]=[CH:15][C:12]([CH:13]=O)=[CH:11][CH:10]=2)=[CH:3][CH:2]=1.C(O)(=O)[CH2:18][C:19]([OH:21])=[O:20].C(OCC)(=O)C>N1C=CC=CC=1.C(O)C>[N:1]1[CH:6]=[CH:5][C:4](/[CH:7]=[CH:8]/[C:9]2[CH:16]=[CH:15][C:12]([CH:13]=[CH:18][C:19]([OH:21])=[O:20])=[CH:11][CH:10]=2)=[CH:3][CH:2]=1

参加物

6

反応物 3

HCID 867Malonic AcidHCID 8857Ethyl AcetateHCID 53747304-(2-(4-Formylphenyl)ethenyl)pyridine

生成物 1

HCID 702455054-[(E)-2-(4-pyridyl)vinyl]cinnamic acid収率 46.6%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 1049Pyridine溶媒

実験手順

To a solution of 4-[(E)-2-(4-pyridyl)vinyl]benzaldehyde (50 mg) in pyridine (0.025 ml) and ethanol (0.075 ml) was added malonic acid (27.4 mg), and the mixture was refluxed for 7 hours. After cooling, ethyl acetate was added thereto, the resulting precipitates were collected by filtration to give 4-[(E)-2-(4-pyridyl)vinyl]cinnamic acid (28 mg).

後処理

  1. temperaturethe mixture was refluxed for 7 hours
  2. temperatureAfter cooling
  3. customthe resulting precipitates
  4. filtrationwere collected by filtration

出典と根拠

ORDレコード
ord-1bfb60053e6c41a9995cfa13720026b7
出典データセット
uspto-grants-2000_07
特許番号
US06083961

反応ノート

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