Ethanolamine → 6-(2-Hydroxyethyl-aminocarbonyl)-2-naphthoic acid

HRID 2287946

反応式

HRID 2287946 の反応式
CO[C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:15]([OH:17])=[O:16])[CH:11]=2)[CH:6]=1)=[O:4].[CH2:18]([CH2:20][NH2:21])[OH:19]>>[OH:19][CH2:18][CH2:20][NH:21][C:3]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]=[C:10]([C:15]([OH:17])=[O:16])[CH:9]=[CH:8]2)=[O:4]

参加物

3

反応物 2

HCID 700EthanolamineHCID 33802176-(Methoxycarbonyl)naphthalene-2-carboxylic acid

生成物 1

HCID 187029066-(2-Hydroxyethyl-aminocarbonyl)-2-naphthoic acid

実験手順

2.1 g of naphthalene-2,6-dicarboxylic acid monomethyl ester and 25 ml of ethanolamine are heated at 150° C. for 3 h. The excess ethanolamine is distilled off in vacuo, and the residue is dissolved in water and the mixture is extracted with ethyl acetate. After acidifying the aqueous phase, the product which is deposited is filtered off with suction and recrystallized from ethanol. 1.2 g of 6-(2-hydroxyethyl-aminocarbonyl)-2-naphthoic acid are obtained.

後処理

  1. distillationThe excess ethanolamine is distilled off in vacuo
  2. dissolutionthe residue is dissolved in water
  3. extractionthe mixture is extracted with ethyl acetate
  4. filtrationthe product which is deposited is filtered off with suction
  5. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-7f7238c97ffa4653a3967569cb05ce1a
出典データセット
uspto-grants-2000_07
特許番号
US06087304

関連ノート

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