HCID 18703984、化合物 → HCID 13244670、化合物
反応式
[CH3:1][C:2]1([CH3:16])[CH2:11][C:10]2[C:9](C(O)=O)=[CH:8][CH:7]=[CH:6][C:5]=2[C:4](=[O:15])[CH2:3]1>N1C2C(=CC=CC=2)C=CC=1.CC(=O)OCC.[Cu]>[CH3:1][C:2]1([CH3:16])[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:15])[CH2:3]1参加物
5
実験手順
2.2 g (10 mmol) of 7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid were heated to 180° C. for 5 h with 2.2 g of copper powder in 22 g of quinoline. After cooling, the mixture was diluted with EA, and the copper was filtered off and then washed several times with dil. hydrochloric acid. After concentration of the organic phase in a rotary evaporator and purification by chromatography on silica gel using cyclohexane/EA 6:1, 0.6 g of 3,3-dimethyl-3,4-dihydro-2H-naphthalen-1-one was obtained.
後処理
- temperatureAfter cooling
- filtrationthe copper was filtered off
- washwashed several times with dil. hydrochloric acid
- customAfter concentration of the organic phase in a rotary evaporator and purification by chromatography on silica gel
出典と根拠
- ORDレコード
- ord-4761e5ed8730430aacea6330a26e22ab
- 出典データセット
- uspto-grants-2000_07
- 特許番号
- US06087399
反応ノート
読み込み中…