Diisopropylethylamine → 4-[4-(4-fluorophenoxy)benzenesulfonylamino]tetrahydropyran-4-carboxylic acid N-benzyloxyamide

Diisopropyl ethylamine (3.89 grams, 0.030 mole) and (benzotriazol-1-yloxy)tris-(dimethylamino)-phosphonium hexafluorophosphate (13.27 grams, 0.030 mole) were added sequentially to a solution of 4-[4-(4-fluorophenoxy)-benzenesulfonylamino] tetrahydropyran-4-carboxylic acid (11.22 grams, 0.028 mole) in anhydrous N,N-dimethylformamide (140 mL). The resulting solution was stirred at room temperature for 16 hours. Additional diisopropyl ethylamine (4.0 mL, 0.051 mole) and O-benzyl hydroxylamine hydrochloride (5.46 grams, 0.034 mole) were then added and the resulting mixture was stirred at 60° C. for 18 hours. After concentration under vacuum, the residue was treated with 0.5N aqueous hydrochloric acid solution and extracted with ethyl acetate. The organic extract was washed with saturated aqueous sodium bicarbonate solution, water, and brine. The solution was dried over magnesium sulfate, filtered and concentrated to one fourth original volume. Addition of an equal volume of hexane precipitated 4-[4-(4-fluorophenoxy)benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid N-benzyloxyamide (11.595 g, 81.6%) as a white crystalline solid (mp 175-176° C.).

1. stirringthe resulting mixture was stirred at 60° C. for 18 hours
2. concentrationAfter concentration under vacuum
3. additionthe residue was treated with 0.5N aqueous hydrochloric acid solution
4. extractionextracted with ethyl acetate
5. extractionThe organic extract
6. washwas washed with saturated aqueous sodium bicarbonate solution, water, and brine
7. dry with materialThe solution was dried over magnesium sulfate
8. filtrationfiltered
9. concentrationconcentrated to one fourth original volume
10. additionAddition of an equal volume of hexane
11. customprecipitated 4-[4-(4-fluorophenoxy)benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid N-benzyloxyamide (11.595 g, 81.6%) as a white crystalline solid (mp 175-176° C.)

ORDレコード

ord-74034e25d23740789a7911d43686178a

出典データセット

uspto-grants-2000_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06087392