Thionyl Chloride → (E)-4-morpholino-2-butenyl chloride hydrochloride

HRID 2288207ノート

反応式

HRID 2288207 の反応式
S(Cl)([Cl:3])=O.[O:5]1[CH2:10][CH2:9][N:8]([CH2:11]/[CH:12]=[CH:13]/[CH2:14]O)[CH2:7][CH2:6]1>ClCCl>[ClH:3].[O:5]1[CH2:10][CH2:9][N:8]([CH2:11]/[CH:12]=[CH:13]/[CH2:14][Cl:3])[CH2:7][CH2:6]1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 22478312(E)-4-morpholino-2-buten-1-ol

生成物 1

HCID 18703519(E)-4-morpholino-2-butenyl chloride hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Thionyl chloride (0.96 ml) was added dropwise to a solution of (E)-4-morpholino-2-buten-1-ol (1.03 g) in dichloromethane (10 ml) at ice-bath temperature. After 3 hours, the reaction mixture was evaporated under reduced pressure and the resulting residue was triturated with ethyl acetate to give (E)-4-morpholino-2-butenyl chloride hydrochloride (0.98 g).

後処理

  1. customthe reaction mixture was evaporated under reduced pressure
  2. customthe resulting residue was triturated with ethyl acetate

出典と根拠

ORDレコード
ord-1cfa6e8636ae467384e4481365fc2171
出典データセット
uspto-grants-2000_07
特許番号
US06087357

反応ノート

読み込み中…