(4,5-Dimethylfuran-2-yl)-(4-methyl-pyridin-2-yl)-methanol → (4,5-Dimethylfuran-2-yl)-(4-methyl-pyridin-2-yl)-methanone

HRID 228826

反応式

HRID 228826 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]([C:10]2[CH:15]=[C:14]([CH3:16])[CH:13]=[CH:12][N:11]=2)[OH:9])[O:5][C:6]=1[CH3:7]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[CH:15]=[C:14]([CH3:16])[CH:13]=[CH:12][N:11]=2)=[O:9])[O:5][C:6]=1[CH3:7]

参加物

4

反応物 1

HCID 23078475(4,5-Dimethylfuran-2-yl)-(4-methyl-pyridin-2-yl)-methanol

生成物 1

HCID 23078347(4,5-Dimethylfuran-2-yl)-(4-methyl-pyridin-2-yl)-methanone収率 77.4%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒2 回HCID 6212Chloroform溶媒

実験手順

(4,5-Dimethylfuran-2-yl)-(4-methyl-pyridin-2-yl)-methanol (900 mg) was dissolved in chloroform (20 ml) to prepare a solution. Manganese dioxide (3.6 g) was added to the solution, and the mixture was stirred at room temperature overnight. Further, manganese dioxide (1.8 g) was then added to the reaction solution, and the mixture was stirred at room temperature for 5 hr. The reaction solution was filtered through Celite, and the solvent was removed from the filtrate by distillation under the reduced pressure, and the residue was purified by column chromatography using hexane-ethyl acetate to give (4,5-dimethylfuran-2-yl)-(4-methyl-pyridin-2-yl)-methanone (690 mg, yield 77%).

後処理

  1. customto prepare a solution
  2. stirringthe mixture was stirred at room temperature for 5 hr
  3. filtrationThe reaction solution was filtered through Celite
  4. customthe solvent was removed from the filtrate by distillation under the reduced pressure
  5. customthe residue was purified by column chromatography

出典と根拠

ORDレコード
ord-b79a5c0abf3748e197e2d1d621430bd9
出典データセット
uspto-grants-2009_07
特許番号
US07560558B2

関連ノート

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