Water → 2-chloro-N-(2-formylphenyl)acetamide

2-Aminobenzaldehyde (650 mg) was dissolved in dichloromethane (20 ml) to prepare a solution. Chloroacetyl chloride (728 mg) was added to the solution, and the mixture was stirred at room temperature overnight. Water was added thereto, and the mixture was extracted with dichloromethane. The dichloromethane layer was washed with water and saturated brine and was dried over anhydrous sodium sulfate. The solvent was removed by distillation under the reduced pressure, and the residue was purified by column chromatography using chloroform to give 2-chloro-N-(2-formylphenyl)-acetamide (1.05 g, yield 99%).

1. customto prepare a solution
2. extractionthe mixture was extracted with dichloromethane
3. washThe dichloromethane layer was washed with water and saturated brine
4. dry with materialwas dried over anhydrous sodium sulfate
5. customThe solvent was removed by distillation under the reduced pressure
6. customthe residue was purified by column chromatography

ORDレコード

ord-7253859b6f0a4d0b8d00265a83cf1321

出典データセット

uspto-grants-2009_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07560558B2