Ethyl 6-methoxy-7-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylate → 6-Methoxy-7-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

HRID 228864ノート

反応式

HRID 228864 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[CH3:13])[NH:9][CH:8]=[C:7]([C:14]([O:16]CC)=[O:15])[C:6]2=[O:19]>[OH-].[Na+]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[CH3:13])[NH:9][CH:8]=[C:7]([C:14]([OH:16])=[O:15])[C:6]2=[O:19]

参加物

3

反応物 1

HCID 12369042Ethyl 6-methoxy-7-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylate

生成物 1

HCID 123690366-Methoxy-7-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid収率 98%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

Ethyl 6-methoxy-7-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylate (25.5 g) was suspended in a 2 M aqueous sodium hydroxide solution (250 ml), and the mixture was heated under reflux for 4 hr. The reaction solution was cooled to room temperature, the aqueous layer was then washed with chloroform and was neutralized with dilute hydrochloric acid. The precipitated crystal was collected by filtration and was washed with water, isopropanol, and hexane in that order to give 6-methoxy-7-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (22.1 g, yield 98%).

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 4 hr
  3. washthe aqueous layer was then washed with chloroform
  4. filtrationThe precipitated crystal was collected by filtration
  5. washwas washed with water, isopropanol, and hexane in that order

出典と根拠

ORDレコード
ord-a435b2078c944f388bd4f04110d56ab9
出典データセット
uspto-grants-2009_07
特許番号
US07560558B2

反応ノート

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