Ethanol → 4-(4-Ethoxymethyl-5-phenyl-oxazol-2-yl)-piperidine

HRID 2288958ノート

反応式

HRID 2288958 の反応式
Cl[CH2:2][C:3]1[N:4]=[C:5]([CH:14]2[CH2:19][CH2:18][N:17](C(=O)C)[CH2:16][CH2:15]2)[O:6][C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[OH-].[Na+].[CH2:25]([OH:27])[CH3:26]>O>[CH2:25]([O:27][CH2:2][C:3]1[N:4]=[C:5]([CH:14]2[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]2)[O:6][C:7]=1[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[CH3:26]

参加物

5

反応物 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 187004361-[4-(4-Chloromethyl-5-phenyl-oxazol-2-yl)-piperidin-1-yl]ethanone

生成物 1

HCID 187004234-(4-Ethoxymethyl-5-phenyl-oxazol-2-yl)-piperidine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 1-[4-(4 -chloromethyl-5-phenyl-oxazol-2-yl)-piperidin-1-yl]-ethanone (0.200 g, 0.627 mmol), prepared as in intermediate 3B, in ethanol (4.5 ml) is treated with a solution of NaOH (0.501 g, 12.55 mmol) in water (1/.5 ml). The reaction mixture is heated to 75 C for 48 hours, concentrated, and the residue partitioned between EtOAc and water. The aqueous phase is washed with EtOAc (twice). The organic phases are combined and washed with saturated brine, dried (Na2SO4) and concentrated to afford the title compound as a light orange oil.

後処理

  1. temperatureThe reaction mixture is heated to 75 C for 48 hours
  2. concentrationconcentrated
  3. customthe residue partitioned between EtOAc and water
  4. washThe aqueous phase is washed with EtOAc (twice)
  5. washwashed with saturated brine
  6. dry with materialdried (Na2SO4)
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-4ad37e2424214caf818e7dc38e70c827
出典データセット
uspto-grants-2000_07
特許番号
US06090825

反応ノート

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