Trifluoroacetic acid → HCID 178521335、化合物

HRID 2289055ノート

反応式

HRID 2289055 の反応式
[N+:1]([C:4]1[CH:45]=[CH:44][C:7]([CH2:8][O:9][C:10]([N:12]=[C:13]([NH:30][C:31]([O:33][CH2:34][C:35]2[CH:40]=[CH:39][C:38]([N+:41]([O-:43])=[O:42])=[CH:37][CH:36]=2)=[O:32])[NH:14][CH2:15][C:16]([NH:18][CH:19]2[CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20]2)=[O:17])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].[F:46][C:47]([F:52])([F:51])[C:48]([OH:50])=[O:49]>ClCCl>[F:46][C:47]([F:52])([F:51])[C:48]([OH:50])=[O:49].[N+:1]([C:4]1[CH:45]=[CH:44][C:7]([CH2:8][O:9][C:10]([N:12]=[C:13]([NH:30][C:31]([O:33][CH2:34][C:35]2[CH:36]=[CH:37][C:38]([N+:41]([O-:43])=[O:42])=[CH:39][CH:40]=2)=[O:32])[NH:14][CH2:15][C:16]([NH:18][CH:19]2[CH2:22][NH:21][CH2:20]2)=[O:17])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 178452375HCID 178452375、化合物

生成物 1

HCID 178521335HCID 178521335、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of the compound (1.92 g), which had been obtained in (1), in anhydrous dichloromethane (10 ml), trifluoroacetic acid (5 ml) was added under ice cooling. The resulting mixture was stirred for one hour, followed by concentration under reduced pressure. The residue was washed with hexane-ether, followed by evaporation of the solvent, whereby 2.78 g of the title target compound were obtained. The product was provided for the subsequent step without purification.

後処理

  1. concentrationfollowed by concentration under reduced pressure
  2. washThe residue was washed with hexane-ether
  3. customfollowed by evaporation of the solvent, whereby 2.78 g of the title target compound
  4. customwere obtained
  5. customThe product was provided for the subsequent step without purification

出典と根拠

ORDレコード
ord-1871abd1f5174d199e0d21ec25e1ecb9
出典データセット
uspto-grants-2000_07
特許番号
US06090802

反応ノート

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