Dimethylformamide → 4-(2-chloroethoxy)benzoyl Chloride

HRID 2289157ノート

反応式

HRID 2289157 の反応式
[Cl:1][CH2:2][CH2:3][O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9](O)=[O:10])=[CH:7][CH:6]=1.CN(C)C=O.C(Cl)(=O)C([Cl:22])=O>ClCCCl>[Cl:1][CH2:2][CH2:3][O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([Cl:22])=[O:10])=[CH:7][CH:6]=1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 123892684-(2-Chloroethoxy)benzoic acid

生成物 1

HCID 110748714-(2-chloroethoxy)benzoyl Chloride

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

In a 250-ml flask are combined 4-(2-chloroethoxy)benzoic acid (2.58 g, 12.9 mmol), dimethylformamide (0.2 ml) and 1,2-dichloroethane (50 ml). Oxalyl chloride (1.35 ml) is added dropwise and the reaction mixture stirred overnight at room temperature. The reaction becomes homogeneous after stirring several hours. After an overnight stir, the solvent is evaporated to dryness, and the solid product is redissolved in 1,2-dichloroethane (2×50 mL) and evaporated. The product is used as is in subsequent reactions.

後処理

  1. customIn a 250-ml flask are combined
  2. stirringafter stirring several hours
  3. stirringAfter an overnight stir
  4. customthe solvent is evaporated to dryness
  5. dissolutionthe solid product is redissolved in 1,2-dichloroethane (2×50 mL)
  6. customevaporated

出典と根拠

ORDレコード
ord-865766fccdd6458aa3d514b217c001c8
出典データセット
uspto-grants-2000_07
特許番号
US06090949

反応ノート

読み込み中…