4-Hydroxymethyl-1-(3-chlorophenyl)-1H-pyridin-2-one → 1-(3-Chloro-phenyl)-2-oxo-1,2-dihydro-pyridine-4-carbaldehyde
反応式
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][N:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[CH:10]=2)[C:5](=[O:16])[CH:4]=1>C(Cl)Cl.O=[Mn]=O>[Cl:15][C:11]1[CH:10]=[C:9]([N:6]2[CH:7]=[CH:8][C:3]([CH:2]=[O:1])=[CH:4][C:5]2=[O:16])[CH:14]=[CH:13][CH:12]=1参加物
4
実験手順
To a solution of 4-hydroxymethyl-1-(3-chlorophenyl)-1H-pyridin-2-one (2.39 g, 10.14 mmol) in CH2Cl2 (250 ml) was added MnO2 (4.41 g, 50.71 mmol) and stirred for 18 hours. The suspension was filtered through celite and the pad washed with additional CH2Cl2 (200 ml). The combined filtrates were evaporated in vacuo and chromatographed (silica gel, 5-20% EtOAc: CH2Cl2 gradient elution) to afford the title compound.
後処理
- filtrationThe suspension was filtered through celite
- washthe pad washed with additional CH2Cl2 (200 ml)
- customThe combined filtrates were evaporated in vacuo
- customchromatographed
- wash(silica gel, 5-20% EtOAc: CH2Cl2 gradient elution)
出典と根拠
- ORDレコード
- ord-8092fa023ba84a0997d2cb42ad3da008
- 出典データセット
- uspto-grants-2000_07
- 特許番号
- US06093737
反応ノート
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