1(2H)-Isoquinolinone → 4-Chloro-1(2H)-isoquinolone

HRID 2289804

反応式

HRID 2289804 の反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9](S(Cl)(=O)=O)[CH:10]=2)[C:5]([Cl:16])=[CH:4][N:3]=1.ClN1C(=[O:23])CCC1=O.C1(=O)C2C(=CC=CC=2)C=CN1>CC#N>[Cl:16][C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2](=[O:23])[NH:3][CH:4]=1

参加物

5

反応物 3

HCID 102841(2H)-IsoquinolinoneHCID 31398ChlorosuccinimideHCID 166582941,4-Dichloroisoquinoline-7-sulfonyl chloride

生成物 1

HCID 8246494-Chloro-1(2H)-isoquinolone

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒2 回

実験手順

1,4-Dichloro-7-isoquinolinesulphonyl chloride ##STR107## A solution of N-chlorosuccinimide (9.66 g, 72 mmol) in MeCN (80 mL) was added dropwise to a stirred solution of 1-(2H)-isoquinolone (10 g, 69 mmol) in MeCN (250 mL) which was being heated under reflux. The mixture was heated under reflux for an additional 1.5 h and then cooled to room temperature. The resulting precipitate was collected by filtration, with MeCN rinsing, and then dried in vacuo to give 4-chloro-1(2H)-isoquinolone (11.3 g, 62.9 mmol) as a pale pink solid.

後処理

  1. temperaturewas being heated
  2. temperatureunder reflux
  3. temperatureThe mixture was heated
  4. temperatureunder reflux for an additional 1.5 h
  5. filtrationThe resulting precipitate was collected by filtration, with MeCN rinsing
  6. customdried in vacuo

出典と根拠

ORDレコード
ord-74292bf0419c4ab89d23b0e9d23420d9
出典データセット
uspto-grants-2000_07
特許番号
US06093731

関連ノート

読み込み中…